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Background: Typhoid fever is caused by salmonella typhi which invades the bloodstream causes systemic involvement & different complications. This study was designed to evaluate the complications of typhoid fever in children admitted to a tertiary care hospital.

Methodology: This retrospective cross-sectional study was conducted at Dr. MR Khan Shishu Hospital & ICH, over twelve months from July 2019 to June 2020 of 100 children aged 6 months to 15 years who were diagnosed with typhoid fever. Complete history, physical examination and investigation were done to reach the complications. Complications were evaluated and data were analyzed.

Results: Complications were found in 37% of typhoid fever cases. Among them, hepatitis, UTI, pneumonia, thrombocytopenia were mostly observed. The majority were boys from poor socio-economic backgrounds. Complications were usually found on the third week and significantly associated with male child, young age, poor socio-economic background, poor oral compliance, delay treatment, leukocytosis and thrombocytopenia.

Conclusion: A significant portion of children with typhoid fever can develop complications.