作者
Shingo Matsumoto, Toshiki Kuno, Takahisa Mikami, Hisato Takagi, Takanori Ikeda, Alexandros Briasoulis, Anna E Bortnick, Daniel Sims, Jason N Katz, Jacob Jentzer, Sripal Bangalore, Carlos L Alviar
发表日期
2023/2/1
来源
American heart journal
卷号
256
页码范围
73-84
出版商
Mosby
简介
Background
Targeted temperature management (TTM) has been recommended after cardiac arrest (CA), however the specific temperature targets and cooling methods (intravascular cooling (IVC) versus surface cooling (SC)) remain uncertain.
Methods
PUBMED and EMBASE were searched until October 8, 2022 for randomized clinical trials (RCTs) investigating the efficacy of TTM after CA. The randomized treatment arms were categorized into the following 6 groups: 31..C to 33..C IVC, 31..C to 33..C SC, 34..C to 36..C IVC, 34..C to 36..C SC, strict normothermia or fever prevention (Strict NT or FP), and standard of care without TTM (No-TTM). The primary outcome was neurological recovery. P-score was used to rank the treatments, where a larger value indicates better performance.
Results
We identified 15 RCTs, involving 5,218 patients with CA. Compared to No-TTM as the reference, the other therapeutic options …
学术搜索中的文章
S Matsumoto, T Kuno, T Mikami, H Takagi, T Ikeda… - American heart journal, 2023