作者
Jae-Jung Kim, Hae-In Lee, Taesung Park, Kyunga Kim, Jong-Eun Lee, Nam Han Cho, Chol Shin, Yoon Shin Cho, Jong-Young Lee, Bok-Ghee Han, Han-Wook Yoo, Jong-Keuk Lee
发表日期
2010/1
期刊
Journal of human genetics
卷号
55
期号
1
页码范围
27-31
出版商
Nature Publishing Group
简介
Height is a complex genetic trait that involves multiple genetic loci. Recently, 44 loci associated with height were identified in Caucasian individuals by large-scale genome-wide association (GWA) studies. To identify genetic variants influencing height in the Korean population, we analyzed GWA data from 8842 Korean individuals and identified 15 genomic regions with one or more sequence variants associated with height (P< 1× 10− 5). Of these, eight loci were newly identified in Koreans (SUPT3H, EXT1, FREM1, PALM2-AKAP2, NUP37-PMCH, IGF1, KRT20 and ANKRD60). The 15 significant loci account for approximately 1.0% of height variation, with a 3.7-cm difference between individuals with⩽ 8 height-increasing alleles (5.1%) and⩾ 19 height-increasing alleles (4.2%). We also examined the associations between height loci and idiopathic short stature (ISS). Five loci (SPAG17, KBTBD8, HHIP, HIST1H1D …
引用总数
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学术搜索中的文章
JJ Kim, HI Lee, T Park, K Kim, JE Lee, NH Cho, C Shin… - Journal of human genetics, 2010