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Aim:

This study aimed to assess the morbid risk of mood disorders in the relatives of schizophrenia probands, in comparison with the families of a sample of healthy controls.

Subjects and Methods:

This study elicited the information on the morbid risk of mood disorders among 5259 relatives of schizophrenia probands (n= 138) and 6734 relatives of healthy controls (n= 138) through direct interview of patients, available relatives of patients and the comparison group. The family history approach using the Family Interview for Genetic Studies was utilised to obtain information on the morbid risk of all relatives that could be recalled. The diagnosis of available relatives was confirmed using the Diagnostic Interview for Genetic Studies. Morbid risk estimates were calculated using the Weinberg shorter method for age correction.

Results:

Morbid risk for mood disorders in the first-, second-and third-degree relatives of …