作者
Joan B Soriano, Inmaculada Alfageme, Pere Almagro, Ciro Casanova, Cristobal Esteban, Juan J Soler-Cataluña, Juan P de Torres, Pablo Martinez-Camblor, Marc Miravitlles, Bartolome R Celli, Jose M Marin
发表日期
2013/3/1
期刊
Chest
卷号
143
期号
3
页码范围
694-702
出版商
Elsevier
简介
Background
The new Global Initiative for Chronic Obstructive Lung Disease (GOLD) update includes airflow limitation, history of COPD exacerbations, and symptoms to classify and grade COPD severity. We aimed to determine their distribution in 11 well-defined COPD cohorts and their prognostic validity up to 10 years to predict time to death.
Methods
Spirometry in all 11 cohorts was postbronchodilator. Survival analysis and C statistics were used to compare the two GOLD systems by varying time points.
Results
Of 3,633 patients, 1,064 (33.6%) were in new GOLD patient group A (low risk, less symptoms), 515 (16.3%) were B (low risk, more symptoms), 561 (17.7%) were C (high risk, less symptoms), and 1,023 (32.3%) were D (high risk, more symptoms). There was great heterogeneity of this distribution within the cohorts (χ2, P < .01). No differences were seen in the C statistics of old vs new GOLD grading to predict …
学术搜索中的文章
JB Soriano, I Alfageme, P Almagro, C Casanova… - Chest, 2013