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Objective: Our objective was to characterize HSV-1 encephalitis seroconversion into the production of anti-NMDAR antibodies. Background: Anti-NMDA receptor autoimmune encephalitis (NMDARAE) is a cell surface autoimmune CNS disorder that decouples the pharmacological action of NMDA receptors from their neuronal networks causing seizures, neuropsychiatric symptoms, movement disorders, and autonomic dysfunction. There are few animal models employed as surrogates for the clinical entity; most involve passive transfer of antibody or active immunization with antigen but lack the ability to interrogate the underlying immune-mediated pathophysiology. Evaluating autoantibody seroconversion of HSV encephalitis may provide clues for the idiopathic encephalitides as well. Design/Methods: We modified a previously reported mouse model of HSV-induced-NMDARAE to include both sexes and two common laboratory mouse strains. We infected 4 groups of mice (male C57Bl/6, female C57Bl/6, male Balb/c …