作者
Varun Kannan, Alexander J Sandweiss, Timothy A Erickson, Jonathan M Yarimi, Alexander Ankar, Victoria A Hardwick, Nikita M Shukla, Timothy E Lotze, Sarah R Risen, James J Riviello, Yi-Chen Lai, Karen K Moeller, Kristen Fisher
发表日期
2023/10/1
期刊
Pediatric Neurology
卷号
147
页码范围
36-43
出版商
Elsevier
简介
Background
We describe a cohort of children with severe myelin oligodendrocyte glycoprotein (MOG)-IgG-associated cerebral cortical encephalitis (CCE), manifesting with bilateral cortical cytotoxic edema and critical neurological illness.
Methods
We retrospectively reviewed our pediatric MOG antibody-associated disease (MOGAD) database and identified patients with specific radiographic pattern of bilateral, multifocal cortical cytotoxic lesions. We collected demographic, clinical, and outcomes data from these patients and compared select variables with radiographically distinct cerebral MOGAD syndromes (case-control analysis). We assessed the correlation of quantitative clinical variables with severity/outcomes measures using simple linear regression.
Results
Sixty-five of 88 total MOGAD cases had cerebral disease, and six of 88 met inclusion criteria for fulminant CCE (f-CCE). Age range was 2 to 7 years; five of …
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V Kannan, AJ Sandweiss, TA Erickson, JM Yarimi… - Pediatric Neurology, 2023
