作者
Nancy A West, Seth T Lirette, Victoria A Cannon, Stephen T Turner, Thomas H Mosley Jr, Beverly G Windham
发表日期
2017/6
期刊
Journal of the American Geriatrics Society
卷号
65
期号
6
页码范围
1282-1288
简介
Objectives
To examine associations between adiposity and adiposity change (loss, stable, gain) and subsequent longitudinal cognitive performance in African Americans in mid and late life.
Design
Cohort study using linear mixed models.
Setting
Genetic Epidemiology Network of Arteriopathy.
Participants
African‐American sibships with hypertension in Jackson, Mississippi (N = 1,108).
Measurements
Waist circumference and body mass index (BMI) were measured at two examinations 5 years apart. Stable adiposity was defined as values within 5% of the first measure. A composite cognitive Z‐score was derived from individual cognitive test Z‐scores at two study visits 6 years apart.
Results
Larger waist circumference was associated with greater rate of cognitive decline during follow‐up (beta = −0.0009 per year, P = .001); BMI, change in waist circumference, and change in BMI were not associated with rate …
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NA West, ST Lirette, VA Cannon, ST Turner… - Journal of the American Geriatrics Society, 2017