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Conclusion

Collectively, the analysis of genetically modified and chemically induced animal models of lung cancer has progressed the understanding of lung cancer pathogenesis. Lung cancer in animal models progresses in a relatively short time frame and under extremely controlled conditions and aids the identification of most relevant oncogenic pathways, which could be novel drug targets. Understanding the genetic changes that occur during cancer progression is complex and depends upon the type of cancer and the stimulus. There remains a lack of robust short-term, easily reproducible, cigarette smoking-induced mouse model which replicate similar clinical features of human lung cancer.