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OBJECTIVE:

Our goal was to investigate the pooled evidence for the effectiveness of using biofeedback to reduce childhood migraine.

DATA SOURCES:

A systematic search was conducted across the databases Medline, Embase, CENTRAL, CINAHL, and PsychINFO.

STUDY SELECTION:

Prospective, randomized controlled trials of biofeedback for migraine among children and adolescents were located in the search.

DATA EXTRACTION:

Data on reduction of mean attack frequency and a series of secondary outcomes, including adverse events, were extracted. Risk of bias was also assessed.

RESULTS:

Forest plots were created by using a fixed effects model, and mean differences were reported. Five studies with a total of 137 participants met the inclusion criteria. Biofeedback reduced migraine frequency (mean difference,–1.97 [95% confidence interval (CI),–2.72 to–1.21]; P<. 00001), attack duration (mean …