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Methods: Adults with at least one component of metabolic syndrome were randomized to TRE (ad libitum eating within a self-selected 12h eating window) or SDA (food pyramid brochure) for 6 months. We analyzed data from participants [n= 42, median (IQR) age: 47 (21) years, body mass index (BMI): 27.8 (5.7) kg/m 2, 76% women] with available pre-/post-intervention assessments for bone turnover markers (BTMs) and/or total body bone mineral content (BMC)/bone mineral density (BMD) by dual-energy x-ray absorptiometry (DXA). Statistical analyses were performed in the total population and according to weight loss responses after 6 months of TRE/SDA (weight loss responders: weight loss above the median of 0.6 kg vs. weight loss non-responders: weight loss below 0.6 kg).

Results: In the total population, there were no between-group differences (TRE vs. SDA) in any bone outcome. Among weight loss …