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Methods: Patients with at least one feature of the metabolic syndrome (central obesity, hypertension, hyperlipidaemia, elevated fasting glucose) whose eating duration was> 14h were randomized to 12h TRE vs. SDA for 6 months, with an optional follow-up until month 12. We compared the weight maintenance from month 6 to 12 with paired t-tests.

Results: Of the 45 patients who completed the intervention, only 23 (TRE n= 13, SDA n= 10, 74% women) could be followed until month 12 due to Covid-19 restrictions and dropouts. We did not observe weight regain from month 6 to 12 after TRE (mean-1.1%, SD 3.7, p= 0.33), nor after SDA (mean-1.8%, SD 2.1, p= 0.03) with no significant difference between groups (p= 0.61).

Conclusion: Both 12h TRE and SDA for 6 months were followed by weight maintenance in the 6-month follow-up period. Follow-up data were limited by the small number of participants. Based on this …