作者
Eun Sook Lee, Jung Min Shin, Soyoung Son, Hyewon Ko, Wooram Um, Seok Ho Song, Jae Ah Lee, Jae Hyung Park
发表日期
2019/1/22
期刊
Advanced Healthcare Materials
页码范围
1801320
出版商
https://onlinelibrary.wiley.com/doi/10.1002/adhm.201801406
简介
Immunotherapy has emerged as a promising approach to treat cancer, since it facilitates eradication of cancer by enhancing innate and/or adaptive immunity without using cytotoxic drugs. Of the immunotherapeutic approaches, significant clinical potentials are shown in cancer vaccination, immune checkpoint therapy, and adoptive cell transfer. Nevertheless, conventional immunotherapies often involve immune‐related adverse effects, such as liver dysfunction, hypophysitis, type I diabetes, and neuropathy. In an attempt to address these issues, polymeric nanomedicines are extensively investigated in recent years. In this review, recent advances in polymeric nanomedicines for cancer immunotherapy are highlighted and thoroughly discussed in terms of 1) antigen presentation, 2) activation of antigen‐presenting cells and T cells, and 3) promotion of effector cells. Also, the future perspectives to develop ideal …
引用总数
20192020202120222023202431112766
学术搜索中的文章
ES Lee, JM Shin, S Son, H Ko, W Um, SH Song, JA Lee… - Advanced Healthcare Materials, 2019