作者
Daniel R Morales, Mitchell M Conover, Seng Chan You, Nicole Pratt, Kristin Kostka, Talita Duarte-Salles, Sergio Fernández-Bertolín, Maria Aragón, Scott L DuVall, Kristine Lynch, Thomas Falconer, Kees van Bochove, Cynthia Sung, Michael E Matheny, Christophe G Lambert, Fredrik Nyberg, Thamir M Alshammari, Andrew E Williams, Rae Woong Park, James Weaver, Anthony G Sena, Martijn J Schuemie, Peter R Rijnbeek, Ross D Williams, Jennifer CE Lane, Albert Prats-Uribe, Lin Zhang, Carlos Areia, Harlan M Krumholz, Daniel Prieto-Alhambra, Patrick B Ryan, George Hripcsak, Marc A Suchard
发表日期
2021/2/1
期刊
The Lancet Digital Health
卷号
3
期号
2
页码范围
e98-e114
出版商
Elsevier
简介
Background
Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been postulated to affect susceptibility to COVID-19. Observational studies so far have lacked rigorous ascertainment adjustment and international generalisability. We aimed to determine whether use of ACEIs or ARBs is associated with an increased susceptibility to COVID-19 in patients with hypertension.
Methods
In this international, open science, cohort analysis, we used electronic health records from Spain (Information Systems for Research in Primary Care [SIDIAP]) and the USA (Columbia University Irving Medical Center data warehouse [CUIMC] and Department of Veterans Affairs Observational Medical Outcomes Partnership [VA-OMOP]) to identify patients aged 18 years or older with at least one prescription for ACEIs and ARBs (target cohort) or calcium channel blockers (CCBs) and thiazide or …
学术搜索中的文章
DR Morales, MM Conover, SC You, N Pratt, K Kostka… - The Lancet Digital Health, 2021