作者
Matthew Traylor, Cathy R Zhang, Poneh Adib-Samii, William J Devan, Owen E Parsons, Silvia Lanfranconi, Sarah Gregory, Lisa Cloonan, Guido J Falcone, Farid Radmanesh, Kaitlin Fitzpatrick, Allison Kanakis, Thomas R Barrick, Barry Moynihan, Cathryn M Lewis, Giorgio B Boncoraglio, Robin Lemmens, Vincent Thijs, Cathie Sudlow, Joanna Wardlaw, Peter M Rothwell, James F Meschia, Bradford B Worrall, Christopher Levi, Steve Bevan, Karen L Furie, Martin Dichgans, Jonathan Rosand, Hugh S Markus, Natalia Rost, International Stroke Genetics Consortium, Sylvia Smoller, John Sorkin, Xingwu Wang, Magdy Selim, Aleksandra Pikula, Philip Wolf, Stephanie Debette, Sudha Seshadri, Paul de Bakker, Daniel Chasman, Kathryn Rexrode, Ida Chen, Jerome Rotter, May Luke, Michelle Sale, Tsong-Hai Lee, Ku-Chou Chang, Mitchell Elkind, Larry Goldstein, Michael James, Monique Breteler, Chris O'Donnell, Didier Leys, Cara Carty, Chelsea Kidwell, Jes Olesen, Pankaj Sharma, Stephen Rich, Turgot Tatlisumak, Olli Happola, Philippe Bijlenga, Carolina Soriano, Eva Giralt, Jaume Roquer, Jordi Jimenez-Conde, Ioana Cotlarcius, John Hardy, Michal Korostynski, Giorgio Boncoraglio, Elena Ballabio, Eugenio Parati, Adamski Mateusz, Andrzej Urbanik, Tomasz Dziedzic, Jeremiasz Jagiella, Jerzy Gasowski, Marcin Wnuk, Rafał Olszanecki, Joanna Pera, Agnieszka Slowik, Karol Józef Juchniewicz, Christopher Levi, Paul Nyquist, Iscia Cendes, Norberto Cabral, Paulo Franca, Anderson Goncalves, Lina Keller, Milita Crisby, Konstantinos Kostulas, Robin Lemmens, Kourosh Ahmadi, Christian Opherk, Marco Duering, Martin Dichgans, Rainer Malik, Mariya Gonik, Julie Staals, Olle Melander, Philippe Burri, Ariane Sadr-Nabavi, Javier Romero, Alessandro Biffi, Chris Anderson, Guido Falcone, Bart Brouwers, Jonathan Rosand, Natalia Rost, Rose Du, Christina Kourkoulis, Thomas Battey, Steven Lubitz, Bertram Mueller-Myhsok, James Meschia, Thomas Brott, Guillaume Pare, Alexander Pichler, Christian Enzinger, Helena Schmidt, Reinhold Schmidt, Stephan Seiler, Susan Blanton, Yoshiji Yamada, Anna Bersano, Tatjana Rundek, Ralph Sacco, Yu-Feng Yvonne Chan, Andreas Gschwendtner, Zhen Deng, Taura Barr, Katrina Gwinn, Roderick Corriveau, Andrew Singleton, Salina Waddy, Lenore Launer, Christopher Chen, Kim En Le, Wei Ling Lee, Eng King Tan, Akintomi Olugbodi, Peter Rothwell, Sabrina Schilling, Vincent Mok, Elena Lebedeva, Christina Jern, Katarina Jood, Sandra Olsson, Helen Kim, Chaeyoung Lee
发表日期
2016/1/12
期刊
Neurology
卷号
86
期号
2
页码范围
146-153
出版商
Lippincott Williams & Wilkins
简介
Objective
For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms.
Methods
We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community populations are also associated in stroke patients. Having established that genetic associations are shared between the 2 populations, we performed a meta-analysis testing which associations with WMHV in stroke-free populations are associated overall when combined with stroke populations.
Results
There were no associations at genome-wide significance with WMHV in stroke patients. All previously reported genome-wide …
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M Traylor, CR Zhang, P Adib-Samii, WJ Devan… - Neurology, 2016