作者
Fushen Sha, Michelle Okwali, Anna Alperovich, Philip C Caron, Lorenzo Falchi, Audrey Hamilton, Paul A Hamlin, Steven M Horwitz, Erel Joffe, Niloufer Khan, Anita Kumar, Matthew J Matasar, Alison J Moskowitz, Ariela Noy, Colette Owens, Lia M Palomba, Ildefonso Rodriguez-Rivera, David Straus, Gottfried von Keudell, Andrew D Zelenetz, Joachim Yahalom, Ahmet Dogan, Heiko Schöder, Venkatraman E Seshan, Gilles Salles, Anas Younes, Connie L Batlevi
发表日期
2022/2/10
期刊
Blood Cancer Journal
卷号
12
期号
2
页码范围
29
出版商
Nature Publishing Group UK
简介
Between 1998 and 2009, a total of 295 patients (median age 58, 53% females) with newly diagnosed early-stage follicular lymphoma (FL) were managed at Memorial Sloan Kettering Cancer Center. Approximately half of patients (137, 46%) underwent initial observation and half (158, 54%) immediate treatment: radiation alone (n = 108), systemic treatment alone (n = 29), or combined modality treatment (n = 21). Median follow-up was 8.4 years (range 0.3–17.2), and 10-year overall survival (OS) was 87.2%. OS was similar between initially-observed and immediately-treated patients (hazard ratio [HR]: 1.25, 95% CI: 0.67–2.36, p = 0.49). For patients receiving radiation alone, 5-year OS was 98.0%. Patients selected for systemic therapy alone had high-risk baseline features and had shorter OS than patients treated with radiation alone (HR 3.38, 95% CI 1.29–8.86, p = 0.01). Combined modality treatment …
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F Sha, M Okwali, A Alperovich, PC Caron, L Falchi… - Blood Cancer Journal, 2022