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ECOG: Eastern Cooperative Oncology Group; LDH: lactate dehydrogenase; MCL: mantle cell lymphoma; OBS: observation group; TX: treatment group; ULN: upper limit of normal.* N= 90.† N= 314.‡ n= 381. § n= 345.‖ n= 379.¶ n= 390.** n= 252.†† n= 322.‡‡ n= 324. Statistically significant P-values in bold. for 2 years or longer (Figure 1B). In univariate analysis, only the presence of lymphadenopathy [defined as any lymphoma-related lymph node (s) measuring> 1.5 cm] was significantly associated with a shorter period of monitoring (HR 2.15; 95% CI: 1.18-3.92; P= 0.01). None of the OBS patients had blastic morphology. Ki-67 value was not significantly associated with length of observation (Figure 1B). Fifteen patients with a Ki-67 30% or over (range, 30-70%) were observed for a median of 22 months (95% CI: 7-33 months). Twenty-five OBS patients underwent tumor molecular profiling using the MSK …