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The adrenal gland is an essential stress-responsive organ that is part of both the hypothalamic-pituitary-adrenal axis and the sympatho-adrenomedullary. The participation of the adrenal cortex in the control of carbohydrate metabolism is unquestionable, but the major pathways employed during deprived glucose states as in diabetes and starvation is not fully explained. A total of forty-eight healthy adult rats (Rattus Novergicus) of both sexes averages weight 200g were used. The rats were maintained on standard laboratory chow and water adlibitum. They were divided into four groups (n= 12);