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Four new norditerpenoids, scabrolides A−D (1−4), along with four known ones, 5−8, have been isolated from the dichloromethane extract of the Taiwanese soft coral Sinularia scabra. The structures of 1−4 were elucidated on the basis of extensive spectroscopic analyses, while the relative configurations were determined by the NOESY experiments. The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines.