作者
Anna Rautanen, Tara C Mills, Anthony C Gordon, Paula Hutton, Michael Steffens, Rosamond Nuamah, Jean-Daniel Chiche, Tom Parks, Stephen J Chapman, Emma E Davenport, Katherine S Elliott, Julian Bion, Peter Lichtner, Thomas Meitinger, Thomas F Wienker, Mark J Caulfield, Charles Mein, Frank Bloos, Ilona Bobek, Paolo Cotogni, Vladimir Sramek, Silver Sarapuu, Makbule Kobilay, V Marco Ranieri, Jordi Rello, Gonzalo Sirgo, Yoram G Weiss, Stefan Russwurm, E Marion Schneider, Konrad Reinhart, Paul AH Holloway, Julian C Knight, Chris S Garrard, James A Russell, Keith R Walley, Frank Stüber, Adrian VS Hill, Charles J Hinds
发表日期
2015/1/1
期刊
The Lancet Respiratory Medicine
卷号
3
期号
1
页码范围
53-60
出版商
Elsevier
简介
Background
Sepsis continues to be a major cause of death, disability, and health-care expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis outcomes, no specific loci have yet been convincingly replicated. The aim of this study was to identify genetic variants that influence sepsis survival.
Methods
We did a genome-wide association study in three independent cohorts of white adult patients admitted to intensive care units with sepsis, severe sepsis, or septic shock (as defined by the International Consensus Criteria) due to pneumonia or intra-abdominal infection (cohorts 1–3, n=2534 patients). The primary outcome was 28 day survival. Results for the cohort of patients with sepsis due to pneumonia were combined in a meta-analysis of 1553 patients from all three cohorts, of whom 359 died within 28 days of admission to the intensive-care unit. The most significantly associated …
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A Rautanen, TC Mills, AC Gordon, P Hutton, M Steffens… - The Lancet Respiratory Medicine, 2015