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According to the available evidence and guidelines, the choice of the VAD should be made on the basis of the following key elements: patient characteristics (eg, type and stage of disease, life expectancy, comorbidities); type of use (ie, continuous versus intermittent); type and expected duration of therapies; VAD history (eg, previous line thrombosis or infection, side used); patient preferences; physical examination of the neck, chest, and upper arms; and ultrasound systematic assessment of all central veins.[...] there are few comparative studies among different VADs, and many of these studies are retrospective or use data collected by reviewing medical records.[...] the published literature reports controversial results.[...] a policy including appropriate choice of the VAD can minimize the rate of catheter-related complications, which is a key element in optimizing the risk-benefit ratio of a CVAD in outpatients …