作者
Anosheh Afghahi, Natasha Purington, Summer S Han, Manisha Desai, Emma Pierson, Maya B Mathur, Tina Seto, Caroline A Thompson, Joseph Rigdon, Melinda L Telli, Sunil S Badve, Christina N Curtis, Robert B West, Kathleen Horst, Scarlett L Gomez, James M Ford, George W Sledge, Allison W Kurian
发表日期
2018/6/15
期刊
Clinical Cancer Research
卷号
24
期号
12
页码范围
2851-2858
出版商
American Association for Cancer Research
简介
Purpose: Tumor-infiltrating lymphocytes (TIL) in pretreatment biopsies are associated with improved survival in triple-negative breast cancer (TNBC). We investigated whether higher peripheral lymphocyte counts are associated with lower breast cancer–specific mortality (BCM) and overall mortality (OM) in TNBC.
Experimental Design: Data on treatments and diagnostic tests from electronic medical records of two health care systems were linked with demographic, clinical, pathologic, and mortality data from the California Cancer Registry. Multivariable regression models adjusted for age, race/ethnicity, socioeconomic status, cancer stage, grade, neoadjuvant/adjuvant chemotherapy use, radiotherapy use, and germline BRCA1/2 mutations were used to evaluate associations between absolute lymphocyte count (ALC), BCM, and OM. For a subgroup with TIL data available, we explored the …
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A Afghahi, N Purington, SS Han, M Desai, E Pierson… - Clinical Cancer Research, 2018