作者
Luis Furuya-Kanamori, Suhail AR Doi, David L Paterson, Stefan K Helms, Laith Yakob, Samantha J McKenzie, Kjetil Garborg, Frida Emanuelsson, Neil Stollman, Matthew P Kronman, Justin Clark, Charlotte A Huber, Thomas V Riley, Archie CA Clements
发表日期
2017/2/1
来源
Journal of Clinical Gastroenterology
卷号
51
期号
2
页码范围
145-150
出版商
LWW
简介
Background:
FMT has been proven to be a safe and highly effective therapeutic option for CDI. Delivery, however, could be via the UGI or LGI routes, and it is unclear as to which route provides better clinical outcome.
Study:
A systematic search for studies that reported the use of FMT for CDI treatment was conducted. Individual patient data that included demographic (age and sex) and clinical (route of FMT delivery, CDI outcome after FMT, and follow-up time) information were obtained. Kaplan-Meier cumulative hazard curves and Cox proportional hazard models were used to assess clinical failure after FMT by the route of delivery.
Results:
Data from 305 patients treated with FMT (208 via LGI route and 97 via UGI route) for CDI were analyzed. At 30 and 90 days, the risk of clinical failure was 5.6% and 17.9% in the UGI group compared with 4.9% and 8.5% in the LGI delivery route group, respectively. A time-varying …
学术搜索中的文章
L Furuya-Kanamori, SAR Doi, DL Paterson, SK Helms… - Journal of Clinical Gastroenterology, 2017