作者
L Li, A Chang, M Naesens, N Kambham, J Waskerwitz, J Martin, C Wong, S Alexander, P Grimm, W Concepcion, O Salvatierra, MM Sarwal
发表日期
2009/6/1
期刊
American Journal of Transplantation
卷号
9
期号
6
页码范围
1362-1372
出版商
Elsevier
简介
Despite early promising patient and graft outcomes with steroid-free (SF) immunosuppression in pediatric kidney transplant recipients, data on long-term safety and efficacy results are lacking. We present our singlecenter experience with 129 consecutive pediatric kidney transplant recipients on SF immunosuppression, with a mean follow-up of 5 years. Outcomes are compared against a matched cohort of 57 concurrent recipients treated with steroid-based (SB) immunosuppression. In the SF group, 87% of kidney recipients with functioning grafts remain corticosteroid-free. Actual intent-to-treat SF (ITT-SF) and still-on-protocol SF patient survivals are 96% and 96%, respectively, actual graft survivals for both groups are 93% and 96%, respectively and actual death-censored graft survivals for both groups are 97% and 99%, respectively. Unprecedented catch-up growth is observed in SF recipients below 12 years of …
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