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The flowers of Macela (Achyrocline satureioides) were extracted by supercritical fluid extraction (SFE) using ethanol as co-solvent. Several experiments were performed at the temperature of 303.15K and 318.15K and pressure of 20MPa and 30MPa. These experiments were accomplished with various compositions and mass flow rate of supercritical solvents in 420min. The extracts from each experiment were analyzed by spectrophotometry and gas chromatography, therefore, the amount of gallic acid and quercetin and the composition of the essential oil were determined. In the second part of the paper, experimental extraction data were correlated using two kinetic models based on mass transfer equations. The adjustable parameters of the models have been determined using genetic algorithm optimization technique. The results of the two models were compared to experimental data by a well-known statistical …