作者
M Cogliati, Ferreira-Paim K., Meyer W., Kwon-Chung K.J., Rickerts V., McCormick-Smith I., F. Hagen, T. Boekhout, Bart Theelen, Desnos-Ollivier M., Dromer F., Inácio J., Alonso B., Colom M.F, Montagna M.T., De Donno A., Susever S., C. Ergin, Velegraki A., M.S. Ellabib, Nardoni S., Macci C., Trovato L., Dipineto L., Akcaglar S., Mlinaric-Missoni E., Bertout S., Vencà A.C., Sampaio A.C., Griseo G., Ranque S., Cerikcioglu N., Marchese A., Vezzulli L., Ilkit M., Pasquale V., Polacheck I., Lockhart S.R.
发表日期
2019
期刊
Fungal Genetics and Biology
卷号
169
页码范围
16-29
简介
A total of 476 European isolates (310 Cryptococcus neoformans var. grubii, 150 C. neoformans var. neoformans, and 16 C. gattii species complex) from both clinical and environmental sources were analyzed by multi-locus sequence typing. Phylogenetic and population genetic analyses were performed. Sequence analysis identified 74 sequence types among C. neoformans var. neoformans (VNIV), 65 among C. neoformans var. grubii (56 VNI, 8 VNII, 1 VNB), and 5 among the C. gattii species complex (4 VGI and 1 VGIV) isolates. ST23 was the most frequent genotype (22%) among VNI isolates which were mostly grouped in a large clonal cluster including 50% of isolates. Among VNIV isolates, a predominant genotype was not identified. A high percentage of autochthonous STs were identified in both VNI (71%) and VNIV (96%) group of isolates. The 16 European C. gattii species complex isolates analyzed in the …
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M Cogliati, M Desnos-Ollivier, I McCormick-Smith… - Fungal Genetics and Biology, 2019