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The improvement of various advancements for water sanitization is a significant issue. Among numerous elective drinking water treatment advances, the well-known disinfectant techniques are ozonation and chlorination to treat drinking water. All through the ozonation procedure, it produces biodegradable organic by-products while in the chlorination process, some risky by-products (trihalomethanes and haloacetic acids) are generated. Because of the possible danger of these results, several water purification methods have been reported, such as ozonation, chlorination, UV, etc. During ozonation, exceptionally reactive hydroxyl radicals are produced, which has a crucial effect on purifying water. In this paper, we have discussed the wide use of ozone disinfectants for water treatment with an emphasis on radical chemistry of ozonization as well as advanced oxidation processes instead of the chlorination process, low-cost ozone generation processes, the impact of ozone and chlorine disinfectants on cryptosporidium oocysts, and the removal of seven strains microbes from drinking water. The favorable circumstances, hindrances of the utilization of ozone and chlorine in wastewater treatment, and their confinements in water treatment innovation just as the elective advances, for example, ozone-based oxidation process, catalytic ozonation, photocatalytic oxidation, and so on are additionally clarified in this paper.