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The objective of this study was to assess the relationship between serum chemerin level and the severity of coronary artery disease (CAD) in Egyptian patients with type 2 diabetes T2DM. The study included 160 subjects; divided into 4 equal groups; T2DM patients having CAD, CAD patients without diabetes, T2DM patients without CAD and a healthy control group. Serum chemerin level, and hs-CRP were measured and the severity of CAD was assessed using SYNTAX score. Serum chemerin was significantly higher in patients with CAD (p< 0.001), with no difference however between diabetic and non-diabetic subjects (p= 0.16). Our results showed a significant positive correlation between serum chemerin and waist circumference (p= 0.024) as well as waist to hip ratio (p= 0.044). A significant association has been observed between the severity of CAD and each of serum chemerin (p< 0.001) and hs-CRP (p= 0 …