作者
Edith M Simmons, Jonathan Himmelfarb, M Tugrul Sezer, Glenn M Chertow, Ravindra L Mehta, Emil P Paganini, Sharon Soroko, Stephanie Freedman, Karen Becker, Daniel Spratt, Yu Shyr, Talp Ikizler, PICARD Study Group
发表日期
2004/4/1
期刊
Kidney international
卷号
65
期号
4
页码范围
1357-1365
出版商
Elsevier
简介
Plasma cytokine levels predict mortality in patients with acute renal failure.
Background
Critically ill patients with acute renal failure (ARF) experience a high mortality rate. Animal and human studies suggest that proinflammatory cytokines lead to the development of a systemic inflammatory response syndrome (SIRS), which is temporally followed by a counter anti-inflammatory response syndrome (CARS). This process has not been specifically described in critically ill patients with ARF.
Methods
The Program to Improve Care in Acute Renal Disease (PICARD) is a prospective, multicenter cohort study designed to examine the natural history, practice patterns, and outcomes of treatment in critically ill patients with ARF. In a subset of 98 patients with ARF, we measured plasma proinflammatory cytokines [interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α (TNF-α)], the acute-phase reactant C-reactive protein (CRP), and …
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EM Simmons, J Himmelfarb, MT Sezer, GM Chertow… - Kidney international, 2004
