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Background: Tuberculous meningitis (TBM) remains a serious health threat for children in developing countries. This study was aimed to analyze findings and duration of cyto-biochemical changes in CSF in children with TBM. Patients and Method: Over a period of 8 years (1989-1996) we have analyzed cyto-biochemical changes in CSF in 202 children with TBM. In 126 cases (62, 4%) was have analyzed duration of pleocytosis till the end of treatment. There were separately analyzed patients with favorable outcome 154 (76, 2%) and patients with unfavorable outcome 48 (23, 8%). Results: CSF cyto-biochemical changes in patients with unfavorable outcome were characterized with lower pleocytosis 234 cells/1mm3 [58-459])(p<, 0001) with lymphocytic predominance 79%[57-96%](p<, 0001) and greater elevation of CSF proteins 2, 26g/L [0, 96-4, 48])(p<, 0001) while glucose level in CSF 1, 59mmol/L [0, 56-2, 51]) was similar comparing to the cases with favorable outcome 1, 49mmol/L [1, 12-1, 78](p= 0,092). Duration of pleocytosis lasted around 70 days [56-92]; significant number of children had pleocytosis till 4 months (12%) and 5 months (8, 7%) while nonsignificant number of children had pleocytosis from 6-10 months 4 children (3, 2%).

Conclusions: Depending on duration of cyto-biochemical changes in CSF and not implementation of daily observed therapy we continue to support the twelve month therapy for TBM in children.