作者
Tom P Freeman, Rebecca A Pope, Matthew B Wall, James A Bisby, Maartje Luijten, Chandni Hindocha, Claire Mokrysz, Will Lawn, Abigail Moss, Michael AP Bloomfield, Celia JA Morgan, David J Nutt, H Valerie Curran
发表日期
2018/1
期刊
International Journal of Neuropsychopharmacology
卷号
21
期号
1
页码范围
21-32
出版商
Oxford University Press
简介
Background
Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here, we investigate the effects of cannabis on listening to music, a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol, which may offset cannabis-related harms.
Methods
Across 3 sessions, 16 cannabis users inhaled cannabis with cannabidiol, cannabis without cannabidiol, and placebo. We compared their response to music relative to control excerpts of scrambled sound during functional Magnetic Resonance Imaging within regions identified in a meta-analysis of music-evoked reward and emotion. All results were False Discovery Rate corrected (P<.05).
Results
Compared with placebo, cannabis without …
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TP Freeman, RA Pope, MB Wall, JA Bisby, M Luijten… - International Journal of Neuropsychopharmacology, 2018