作者
Sarah Abou Alaiwi, Amin H Nassar, Wanling Xie, Ziad Bakouny, Jacob E Berchuck, David A Braun, Sylvan C Baca, Pier Vitale Nuzzo, Ronan Flippot, Tarek H Mouhieddine, Liam F Spurr, Yvonne Y Li, Taiwen Li, Abdallah Flaifel, John A Steinharter, Claire A Margolis, Natalie I Vokes, Heng Du, Sachet A Shukla, Andrew D Cherniack, Guru Sonpavde, Robert I Haddad, Mark M Awad, Marios Giannakis, F Stephen Hodi, X Shirley Liu, Sabina Signoretti, Cigall Kadoch, Matthew L Freedman, David J Kwiatkowski, Eliezer M Van Allen, Toni K Choueiri
发表日期
2020/8/1
期刊
Cancer immunology research
卷号
8
期号
8
页码范围
1075-1084
出版商
American Association for Cancer Research
简介
Prior data have variably implicated the inactivation of the mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) complex with increased tumor sensitivity to immune checkpoint inhibitors (ICI). Herein, we examined the association between mSWI/SNF variants and clinical outcomes to ICIs. We correlated somatic loss-of-function (LOF) variants in a predefined set of mSWI/SNF genes (ARID1A, ARID1B, SMARCA4, SMARCB1, PBRM1, and ARID2) with clinical outcomes in patients with cancer treated with systemic ICIs. We identified 676 patients from Dana-Farber Cancer Institute (DFCI, Boston, MA) and 848 patients from a publicly available database from Memorial Sloan Kettering Cancer Center (MSKCC, New York, NY) who met the inclusion criteria. Multivariable analyses were conducted and adjusted for available baseline factors and tumor mutational burden. Median follow-up was 19.6 (17.6–22.0 …
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S Abou Alaiwi, AH Nassar, W Xie, Z Bakouny… - Cancer immunology research, 2020