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Global fiber reconstruction aims at providing a consistent view of the fiber architecture in the whole volume of cerebral white matter on the basis of diffusion-sensitized magnetic resonance imaging. A new realization of this principle is presented. The method utilizes data acquired with high angular resolution diffusion imaging (HARDI), a measurement method that fulfills clinical requirements. For the first time among global reconstruction methods, the computation time is acceptable for a broad class of practical applications. The method does not involve any boundary conditions that prescribe the location of the ends of reconstructed fibers. This helps to minimize necessary user interaction and operator dependence. Results obtained in a physical phantom demonstrate a high reconstruction quality. In vivo results have been obtained in several volunteers. The algorithm found a number of prominent fascicles including …