作者
AS Siebuhr, Kristian Kjær Petersen, Lars Arendt-Nielsen, Line Lindhardt Egsgaard, T Eskehave, C Christiansen, Ole Simonsen, HC Hoeck, MA Karsdal, AC Bay-Jensen
发表日期
2014/1/1
期刊
Osteoarthritis and Cartilage
卷号
22
期号
1
页码范围
44-50
出版商
WB Saunders
简介
Objectives
Osteoarthritis (OA) is a degenerative disease with a subset of patients experiencing joint inflammation, but C-reactive protein (CRP) has shown limited use in OA as a diagnostic marker. The aim was to identify subpopulations of patients with high or low levels of acute (high sensitive CRP (hsCRP)) and/or matrix metalloproteinase (MMP) derived inflammation (CRPM) and investigate the subpopulations' association with biomarkers of collagen degradation and Kellgren–Lawrence (KL) score.
Methods
hsCRP, CRPM and MMP-degraded type I, II and III collagen (type I collagen degraded by MMP (C1M), type II collagen degraded by MMP (C2M) and type III collagen degraded by MMP (C3M)) were quantified by enzyme linked immunosorbent assays (ELISA) in serum of 342 patients with symptomatic knee OA of which 60 underwent total knee replacement (TKR). KL was obtained. Patients were divided into …
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AS Siebuhr, KK Petersen, L Arendt-Nielsen… - Osteoarthritis and Cartilage, 2014