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The use of conditioning pain modulation (CPM) is hampered by poor reproducibility and lack of user‐independent paradigms. This study refined the CPM paradigm by applying user‐independent cuff algometry.

In 20 subjects, the CPM effect of conditioning with cuff stimulation on the arm was investigated by pain test stimuli on the contralateral leg before and in parallel with different cuff conditionings (10, 30, 60 kPa/60 s; 30, 60 kPa/10 s). As test stimulus, another cuff was inflated (1 kPa/s) until the subjects detected the pain tolerance threshold (PTT) during which the pain detection threshold (PDT) and the pressure at a pain intensity of 6 cm on a 10‐cm visual analogue scale (PVAS6) were extracted. For comparison, pressure pain thresholds (PPTs) as test stimuli were recorded by the user‐dependent handheld pressure algometry. Combinations of cuff locations for conditioning (pain intensity …