作者
Yi He, Anne Sofie Siebuhr, Niels Ulrik Brandt-Hansen, Jianxia Wang, Di Su, Qinlong Zheng, Ole Simonsen, Kristian Kjær Petersen, Lars Arendt-Nielsen, Thomas Eskehave, Hans Christian Hoeck, Morten Asser Karsdal, Anne C Bay-Jensen
发表日期
2014/12
期刊
BMC musculoskeletal disorders
卷号
15
页码范围
1-10
出版商
BioMed Central
简介
Background
Osteoarthritis (OA) is the most common degenerative joint disease, of which the pathogenesis is inadequately understood. Hypertrophy-like changes have been observed as part of the progression of OA. The aim of the study was to develop and characterize a novel biomarker of chondrocytes hypertrophy and investigate how this marker was associated with cartilage degradation and inflammation in patients with various degrees of OA.
Methods
A competitive ELISA, C-Col10, applying a well-characterized monoclonal antibody was developed as a biomarker of chondrocyte hypertrophy through measurement of type X collagen (ColX). The levels of C-Col10, C2M (matrix metalloproteinase-derived fragments of type II collagen) and hsCRP (high sensitive C-reactive protein) were quantified by ELISAs in serum of 271 OA patients stratified by …
学术搜索中的文章
Y He, AS Siebuhr, NU Brandt-Hansen, J Wang, D Su… - BMC musculoskeletal disorders, 2014