作者
Kuan-Pei Lin, Ting-Kuang Yeh, Yu-Chuan Chuang, Li-An Wang, Yun-Ching Fu, Po-Yu Liu
发表日期
2023
来源
International Journal of General Medicine
卷号
16
页码范围
317
出版商
Dove Press
简介
Infective endocarditis is a potentially fatal condition, and identifying the pathogen is crucial to optimizing antibiotic treatment. While a blood culture takes time and may yield negative results, it remains the gold standard for diagnosis, blood culture-negative endocarditis, which accounts for up to 20% of infective endocarditis cases, poses a clinical challenge with increasing mortality. To better understand the etiology of blood culture-negative infective endocarditis, we reviewed non-culture-based strategies and compared the results. Serology tests work best in limited pathogens, such as Coxiella burnetii and Bartonella infections. Most of the pathogens identified by broad-range PCR tests are Streptococcus spp, Staphylococcus spp and Propionibacterium spp. adding specific real-time PCR assays to the systematic PCR testing of patients with blood culture-negative endocarditis will increase the efficiency of diagnosis …
引用总数
学术搜索中的文章
KP Lin, TK Yeh, YC Chuang, LA Wang, YC Fu, PY Liu - International Journal of General Medicine, 2023