作者
Aaron I Vinik, Marie Nevoret, Carolina Casellini, Henri Parson
发表日期
2013/8
来源
Current diabetes reports
卷号
13
页码范围
517-532
出版商
Springer US
简介
In this review of thermoregulatory function in health and disease, we review the basic mechanisms controlling skin blood flow of the hairy and glabrous skin and illustrate the major differences in blood flow to glabrous skin, which is, in essence, sympathetically mediated, while hairy skin is dependent upon neuropeptidergic signals, nitric oxide, and prostaglandin, among others. Laser Doppler methods of quantification of blood flow—in response to iontophoresis of acetylcholine or heat—and nociceptor-mediated blood flow have relatively uniformly demonstrated an impaired capacity to increase blood flow to the skin in diabetes and in its forerunners, prediabetes and the metabolic syndrome. This reduced capacity is likely to be a significant contributor to the development of foot ulcerations and amputations in diabetes, and means of increasing blood flow are clearly needed. Understanding the pathogenic …
学术搜索中的文章
AI Vinik, M Nevoret, C Casellini, H Parson - Current diabetes reports, 2013