作者
Mark A Feitelson, Alla Arzumanyan, Rob J Kulathinal, Stacy W Blain, Randall F Holcombe, Jamal Mahajna, Maria Marino, Maria L Martinez-Chantar, Roman Nawroth, Isidro Sanchez-Garcia, Dipali Sharma, Neeraj K Saxena, Neetu Singh, Panagiotis J Vlachostergios, Shanchun Guo, Kanya Honoki, Hiromasa Fujii, Alexandros G Georgakilas, Alan Bilsland, Amedeo Amedei, Elena Niccolai, Amr Amin, S Salman Ashraf, Chandra S Boosani, Gunjan Guha, Maria Rosa Ciriolo, Katia Aquilano, Sophie Chen, Sulma I Mohammed, Asfar S Azmi, Dipita Bhakta, Dorota Halicka, W Nicol Keith, Somaira Nowsheen
发表日期
2015/12/1
来源
Seminars in cancer biology
卷号
35
页码范围
S25-S54
出版商
Academic Press
简介
Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin …
学术搜索中的文章
MA Feitelson, A Arzumanyan, RJ Kulathinal, SW Blain… - Seminars in cancer biology, 2015