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Six species of fishes (Tilapia zilli, Clarias anguillaris, Protoptenus, Oreochromis niloticus, Eutropius niloticus and Synodentis budgetti) were caught from Lake Chad in Doron Buhari between the periods of February to September 2008. The bone, liver, stomach, gills and Kidney from the six species were carefully dissected for the determination of heavy metals. Levels of heavy metals were determined using Perkin-Elmer Analyst 300 Atomic Absorption Spectrophotometry (AAS). The maximum concentration of heavy metals studied was observed in the liver tissues, while bone tissues had the least concentration. The highest level of copper was observed in O. niloticus, while E. niloticus shows the least. For Co concentrations, the maximum was obtained in E. niloticus and the minimum in C. anguillaris. High levels of Pb, Fe and Cd were found in the liver tissues of T. zilli, while S. budgetti had the least concentrations …