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Results

Overall scores for SPPB, PHC, and PF were poor relative to population norms and in line with other studies in ESRD. In the Daily Trial, subjects randomized to frequent compared with conventional in-center hemodialysis experienced no significant change in SPPB (adjusted mean change of− 0.20±0.19 versus− 0.41±0.21, P= 0.45) but experienced significant improvement in PHC (3.4±0.8 versus 0.4±0.8, P= 0.009) and a relatively large change in PF that did not reach statistical significance. In the Nocturnal Trial, there were no significant differences among subjects randomized to frequent compared with conventional hemodialysis in SPPB (adjusted mean change of− 0.92±0.44 versus− 0.41±0.43, P= 0.41), PHC (2.7±1.4 versus 2.1±1.5, P= 0.75), or PF (− 3.1±3.5 versus 1.1±3.6, P= 0.40).

Conclusions

Frequent in-center hemodialysis compared with conventional in-center hemodialysis improved self-reported …