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The purpose of this study is to examine the mediator role of psychological empowerment in the effects of organizational support provided by organization managers to employees on employees’ work life quality. In alignment with this purpose, the variables of “organizational support” and “work life quality” were used. Organizational support refers to employees’ perceptions of being values by their organizations and thus, the understanding of their organization takes employee well-being and interests into consideration while “work life quality” refers to an emotional outcome of employees’ evaluation of their jobs and the work environment they are in. In addition to these two variables, “psychological empowerment” which refers to employees’ psychological state on having control of employees on their jobs, was included as the mediator variable in the study. In the study, the data were collected from 242 administrative staff working in a state university through a survey instrument and analyzed with structural equational modelling. The results showed that organizational support has positive effects on work life quality and psychological empowerment. Similarly, a positive relationship was found between psychological empowerment and work life quality. Additionally, a mediator role of psychological empowerment on the interaction between organizational support and work life quality was identified.