作者
Houriiyah Tegally, Eduan Wilkinson, Richard J Lessells, Jennifer Giandhari, Sureshnee Pillay, Nokukhanya Msomi, Koleka Mlisana, Jinal N Bhiman, Anne von Gottberg, Sibongile Walaza, Vagner Fonseca, Mushal Allam, Arshad Ismail, Allison J Glass, Susan Engelbrecht, Gert Van Zyl, Wolfgang Preiser, Carolyn Williamson, Francesco Petruccione, Alex Sigal, Inbal Gazy, Diana Hardie, Nei-yuan Hsiao, Darren Martin, Denis York, Dominique Goedhals, Emmanuel James San, Marta Giovanetti, José Lourenço, Luiz Carlos Junior Alcantara, Tulio de Oliveira
发表日期
2021/3
期刊
Nature medicine
卷号
27
期号
3
页码范围
440-446
出版商
Nature Publishing Group US
简介
The first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in South Africa was identified on 5 March 2020, and by 26 March the country was in full lockdown (Oxford stringency index of 90). Despite the early response, by November 2020, over 785,000 people in South Africa were infected, which accounted for approximately 50% of all known African infections. In this study, we analyzed 1,365 near whole genomes and report the identification of 16 new lineages of SARS-CoV-2 isolated between 6 March and 26 August 2020. Most of these lineages have unique mutations that have not been identified elsewhere. We also show that three lineages (B.1.1.54, B.1.1.56 and C.1) spread widely in South Africa during the first wave, comprising ~42% of all infections in the country at the time. The newly identified C lineage of SARS-CoV-2, C.1, which has 16 nucleotide mutations as compared with the …
学术搜索中的文章
H Tegally, E Wilkinson, RJ Lessells, J Giandhari… - Nature medicine, 2021