作者
Jackson A Seukep, Aimé G Fankam, Doriane E Djeussi, Igor K Voukeng, Simplice B Tankeo, Jaurès AK Noumdem, Antoine HLN Kuete, Victor Kuete
发表日期
2013/12
期刊
Springerplus
卷号
2
页码范围
1-8
出版商
Springer International Publishing
简介
The morbidity and mortality caused by bacterial infections significantly increased with resistance to commonly used antibiotics. This is partially due to the activation of efflux pumps in Gram-negative bacteria. The present work designed to assess the in vitro antibacterial activities of seven Cameroonian dietary plants (Sesamum indicum, Sesamum radiatum, Cinnamomum zeylanicum, Corchous olitorius, Cyperus esculentus, Adansonia digitata, Aframomum kayserianum), against multidrug resistant (MDR) Gram-negative bacteria over expressing active efflux pumps. The standard phytochemical methods were used to detect the main classes of secondary metabolites in the extracts. The antibacterial activities of the studied extracts in the absence or presence of an efflux pump inhibitor (PAβN) were evaluated using liquid microbroth dilution method. The results obtained indicated that apart from the extract of C …
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