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For thousands of years, plants and herbs have been a tremendous source of food and medicine. Various parts of Sida acuta have been reported in many studies to be used by indigenous people from tropical countries to manage some health problems: rheumatic affections, azoospermia, oligospermia and spermatorrhea, leucorrhoea, wounds, sciatica, nervous and heart diseases, cold, cough, asthma, tuberculosis and respiratory diseases, disorders of the blood, bile and liver, elephantiasis, hemorrhoids, ulcers, gastric disorders and abdominal pain, headache, fever and malaria, skin diseases, worms, diarrhea and dysentery, venereal diseases, renal inflammation, toothache and snake bites. Sida acuta has been scientifically studied for its numerous pharmacological profiles such as: antioxidant, antimicrobial and antibacterial, antimalarial, cardiovascular, antiulcer, analgesic and anti-inflammatory, antipyretic, hepatoprotective, hypoglycemic, insecticidal and anticancer. Moreover, it has been proved that there was no mortality in rats administered with this plant extract up to a dose level of 2000mg/Kg body weight. Bioactive constituents such as alkaloids, saponins, coumarins, steroids, tannins, phenolic compounds, cardiac glycosides, sesquiterpene and flavonoids, significantly present in the plant extract, account for its multiple properties and uses in traditional medicine. This review study is an attempt to give a detailed survey of the literature on the ethnomedicinal uses, phytochemical and pharmacological profiles, as well as the toxicity of Sida acuta.