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Objectives: We compare the symptomatic effects of 300 or 600 mg daily of ASU in patients with knee osteoarthritis. Methods: A multicenter, double blind, study comparing a daily intake of 300 mg or 600 mg of ASU and placebo. The study lasted 3 months and involved patients of both genders, aged 45 to 80 years and presenting with femoro-tibial knee osteoarthritis. The primary endpoint was NSAIDs and analgesics intake between D30 and D90. Results: All efficacy parameters were significantly improved (p< 0.01), in the two ASU groups compared to the placebo group. At D90, NSAIDs and analgesics intake decreased by more than 50% in 71% of the patients receiving ASU 300 mg or 600 mg, compared to 36% of the patients receiving placebo. From D0 to D90 Lequesne's index dropped by 3.9 and 2.9 points in ASU 300 mg and 600 mg groups, respectively, against 1.6 in those receiving placebo. Conclusion: The …