作者
Virginia Byers Kraus, Bruce Burnett, Javier Coindreau, Susan Cottrell, David Eyre, Michael Gendreau, Jennifer Gardiner, Patrick Garnero, John Hardin, Yves Henrotin, Dick Heinegård, Amy Ko, LS Lohmander, Gloria Matthews, Joseph Menetski, Roland Moskowitz, Stefano Persiani, AR Poole, J-C Rousseau, Martin Todman
发表日期
2011/5/1
期刊
Osteoarthritis and Cartilage
卷号
19
期号
5
页码范围
515-542
出版商
WB Saunders
简介
OBJECTIVE
Osteoarthritis (OA) is a chronic and slowly progressive disease for which biomarkers may be able to provide a more rapid indication of therapeutic responses to therapy than is currently available; this could accelerate and facilitate OA drug discovery and development programs. The goal of this document is to provide a summary and guide to the application of in vitro (biochemical and other soluble) biomarkers in the development of drugs for OA and to outline and stimulate a research agenda that will further this goal.
METHODS
The Biomarkers Working Group representing experts in the field of OA biomarker research from both academia and industry developed this consensus document between 2007 and 2009 at the behest of the Osteoarthritis Research Society International Federal Drug Administration initiative (OARSI FDA initiative).
RESULTS
This document summarizes definitions and …
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VB Kraus, B Burnett, J Coindreau, S Cottrell, D Eyre… - Osteoarthritis and Cartilage, 2011