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Surviving cardiac arrest is characterized by cognitive, psychological, and functional impairments and apprehension over long-term prognosis. We first estimated the proportion of clinically significant depression and anxiety in cardiac arrest survivors and their informal caregivers, then examined the association between depression and anxiety with worse quality of life (QoL).

In an online survey, cardiac arrest survivors and caregivers reported demographic and arrest characteristics, the Patient Health Questionnaire-4 (PHQ-4), and the WHOQOL-BREF physical, psychological, and social QoL subscales. Six multiple regression models (three for survivors and three for caregivers) tested associations between PHQ-4 scores with each QoL subscale, adjusted for the following: for survivors – functional dependence, self-reported memory problems, sex, income, months since arrest, and age; for …