作者
Amarendra Pegu, Sarah E O’Connell, Stephen D Schmidt, Sijy O’Dell, Chloe A Talana, Lilin Lai, Jim Albert, Evan Anderson, Hamilton Bennett, Kizzmekia S Corbett, Britta Flach, Lisa Jackson, Brett Leav, Julie E Ledgerwood, Catherine J Luke, Mat Makowski, Martha C Nason, Paul C Roberts, Mario Roederer, Paulina A Rebolledo, Christina A Rostad, Nadine G Rouphael, Wei Shi, Lingshu Wang, Alicia T Widge, Eun Sung Yang, mRNA-1273 Study Group §, John H Beigel, Barney S Graham, John R Mascola, Mehul S Suthar, Adrian B McDermott, Nicole A Doria-Rose, Jae Arega, John H Beigel, Wendy Buchanan, Mohammed Elsafy, Binh Hoang, Rebecca Lampley, Aparna Kolhekar, Hyung Koo, Catherine Luke, Mamodikoe Makhene, Seema Nayak, Rhonda Pikaart-Tautges, Paul C Roberts, Janie Russell, Elisa Sindall, Jim Albert, Pratap Kunwar, Mat Makowski, Evan J Anderson, Amer Bechnak, Mary Bower, Andres F Camacho-Gonzalez, Matthew Collins, Ana Drobeniuc, Venkata Viswanadh Edara, Srilatha Edupuganti, Katharine Floyd, Theda Gibson, Cassie M Grimsley Ackerley, Brandi Johnson, Satoshi Kamidani, Carol Kao, Colleen Kelley, Lilin Lai, Hollie Macenczak, Michele Paine McCullough, Etza Peters, Varun K Phadke, Paulina A Rebolledo, Christina A Rostad, Nadine Rouphael, Erin Scherer, Amy Sherman, Kathy Stephens, Mehul S Suthar, Mehgan Teherani, Jessica Traenkner, Juton Winston, Inci Yildirim, Lee Barr, Joyce Benoit, Barbara Carste, Joe Choe, Maya Dunstan, Roxanne Erolin, Jana ffitch, Colin Fields, Lisa A Jackson, Erika Kiniry, Susan Lasicka, Stella Lee, Matthew Nguyen, Stephanie Pimienta, Janice Suyehira, Michael Witte, Hamilton Bennett, Nedim Emil Altaras, Andrea Carfi, Marjorie Hurley, Brett Leav, Rolando Pajon, Wellington Sun, Tal Zaks, Rhea N Coler, Sasha E Larsen, Kathleen M Neuzil, Lisa C Lindesmith, David R Martinez, Jennifer Munt, Michael Mallory, Caitlin Edwards, Ralph S Baric, Nina M Berkowitz, Eli A Boritz, Kevin Carlton, Kizzmekia S Corbett, Pamela Costner, Adrian Creanga, Nicole A Doria-Rose, Daniel C Douek, Britta Flach, Martin Gaudinski, Ingelise Gordon, Barney S Graham, LaSonji Holman, Julie E Ledgerwood, Kwanyee Leung, Bob C Lin, Mark K Louder, John R Mascola, Adrian B McDermott, Kaitlyn M Morabito, Laura Novik, Sarah O’Connell, Sijy O’Dell, Marcelino Padilla, Amarendra Pegu, Stephen D Schmidt, Wei Shi, Phillip A Swanson, Chloe A Talana, Lingshu Wang, Alicia T Widge, Eun Sung Yang, Yi Zhang, James D Chappell, Mark R Denison
发表日期
2021/9/17
期刊
Science
卷号
373
期号
6561
页码范围
1372-1377
出版商
American Association for the Advancement of Science
简介
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations may diminish vaccine-induced protective immune responses, particularly as antibody titers wane over time. Here, we assess the effect of SARS-CoV-2 variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.429 (Epsilon), B.1.526 (Iota), and B.1.617.2 (Delta) on binding, neutralizing, and angiotensin-converting enzyme 2 (ACE2)–competing antibodies elicited by the messenger RNA (mRNA) vaccine mRNA-1273 over 7 months. Cross-reactive neutralizing responses were rare after a single dose. At the peak of response to the second vaccine dose, all individuals had responses to all variants. Binding and functional antibodies against variants persisted in most subjects, albeit at low levels, for 6 months after the primary series of the mRNA-1273 vaccine. Across all assays, B.1.351 had the lowest antibody recognition. These data …
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A Pegu, SE O'Connell, SD Schmidt, S O'Dell… - Science, 2021