作者
Tongqing Zhou, Lingshu Wang, John Misasi, Amarendra Pegu, Yi Zhang, Darcy R Harris, Adam S Olia, Chloe Adrienna Talana, Eun Sung Yang, Man Chen, Misook Choe, Wei Shi, I-Ting Teng, Adrian Creanga, Claudia Jenkins, Kwanyee Leung, Tracy Liu, Erik-Stephane D Stancofski, Tyler Stephens, Baoshan Zhang, Yaroslav Tsybovsky, Barney S Graham, John R Mascola, Nancy J Sullivan, Peter D Kwong
发表日期
2022/3/24
期刊
Science
卷号
376
期号
6591
页码范围
eabn8897
出版商
American Association for the Advancement of Science
简介
The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (Omicron) variant and its resistance to neutralization by vaccinee and convalescent sera are driving a search for monoclonal antibodies with potent neutralization. To provide insight into effective neutralization, we determined cryo–electron microscopy structures and evaluated receptor binding domain (RBD) antibodies for their ability to bind and neutralize B.1.1.529. Mutations altered 16% of the B.1.1.529 RBD surface, clustered on an RBD ridge overlapping the angiotensin-converting enzyme 2 (ACE2)–binding surface and reduced binding of most antibodies. Substantial inhibitory activity was retained by select monoclonal antibodies—including A23-58.1, B1-182.1, COV2-2196, S2E12, A19-46.1, S309, and LY-CoV1404—that accommodated these changes and neutralized B.1.1.529. We identified combinations of …
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T Zhou, L Wang, J Misasi, A Pegu, Y Zhang, DR Harris… - Science, 2022